

It is believed that interactions between the genetic risk and environment may play a role in the development of schizophrenia.The exact cause of paranoid schizophrenia is unknown but several risk factors may contribute to the development of the disorder, such as: Lack of interest in spending time with others or having fun.“Negative” symptoms of schizophrenia are not as common in patients with paranoid forms of the disorder, though they can occur and may include: Talking about a lot of things before getting to the point.Problems thinking in an organized way/difficulty thinking clearly.Hearing voices that threaten or give commands.Hearing, seeing, feeling, smelling, or tasting things that aren't there.Delusions of being someone exalted or being on a special mission.

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We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. In this understanding, medication that acts on dopamine receptors changes how the brain responds to dopamine, making medication less effective. Dopamine sensitivity: Another theory suggests dopamine is critical.Some researchers believe that this form of the condition occurs because of a dysfunction of the neurotransmitters glutamate and gamma-aminobutyric acid, making dopamine more active in the brain. Schizophrenia subtype: Some researchers believe that treatment-resistant schizophrenia is a schizophrenia subtype, with a different disease course.
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They also think certain types of neuroinflammation make treatment-resistant schizophrenia more likely. Neuroinflammation: Some researchers believe that neuroinflammation, which involves inflammation in the brain and nervous system, contributes to the development of schizophrenia.Some potential explanations for why some individuals develop treatment-resistant schizophrenia include: Some evidence suggests that dopamine is overactive in people with schizophrenia. Dopamine, which supports reward and motivation, may be especially important. Several neurotransmitters play a role in schizophrenia.
PARANOID SCHIZOPHRENIA SYMPTOMS HOW TO
However, researchers do not know what causes it or how to predict who will respond to treatment. Treatment-resistant schizophrenia is common, affecting about a third of people with schizophrenia.
